Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation
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- 作者：Gabriella Testaa ; Erica Staurenghia ; Chiara Zerbinatib ; Simona Gargiuloa ; Luigi Iulianob ; Giorgio Giacconec ; Fausto Fantò ; d ; Giuseppe Polia ; Gabriella Leonarduzzia ; 1 ; gabriella.leonarduzzi@unito.it" class="auth_mail" title="E-mail the corresponding author ; Paola Gambaa ; 1
- 关键词：α-epoxy ; 5α ; 6α-epoxycholesterol ; β-epoxy ; 5β ; 6β-epoxycholesterol ; 24-OH ; 24-hydroxycholesterol ; 25-OH ; 25-hydroxycholesterol ; 27-OH ; 27-hydroxycholesterol ; 4β-OH ; 4β-hydroxycholesterol ; 7β-OH ; 7β-hydroxycholesterol ; 7α-OH ; 7α-hydroxycholesterol ; 7-K ; 7-ketocholesterol ; 7-OH-4-C ; 7α-hydroxy-3-oxo-4-cholestenoic acid ; Aβ ; amyloid β ; AD ; Alzheimer's disease ; BBB ; blood brain barrier ; COX-2 ; cyclooxigenase 2 ; CSF ; cerebrospinal fluid ; IL ; interleukin ; LXR ; liver X receptor ; MCI ; mild cognitive impai
- 刊名：Redox Biology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：10
- 期：Complete
- 页码：24-33
- 全文大小：1183 K
文摘
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Changes in brain oxysterol levels may influence AD progression.
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Oxysterol accumulation in the brain may amplify neuroinflammation.
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SIRT-1 loss during AD progression may favor neuroinflammation.
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Oxysterols and SIRT-1 might be useful markers for early AD diagnosis.