Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach
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- 作者：Gaetano Serviddioa ; 1 ; gaetano.serviddio@unifg.it" class="auth_mail" title="E-mail the corresponding author ; Francesco Bellantia ; 1 ; Rosanna Villania ; Rosanna Tamborraa ; Chiara Zerbinatib ; Maria Blondaa ; Marco Ciacciarellib ; Giuseppe Polic ; Gianluigi Vendemialea ; Luigi Iulianob
- 关键词：NAFLD ; Non-Alcoholic Fatty Liver Disease ; NAFL ; Non-Alcoholic Fatty Liver ; NASH ; Non-Alcoholic SteatoHepatitis ; FA ; fatty acids ; TG ; triglycerides ; SFA ; saturated fatty acids ; CYP ; cytochrome ; HFA ; high fatty acids ; HCh ; high cholesterol ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; FFA ; free fatty acids ; 7α-OHC ; 7α-hydroxycholesterol ; 7β-OHC ; 7β-hydroxycholesterol ; 27-OHC ; 27-hydroxycholesterol ; 25-OHC ; 25-hydroxycholesterol ; 4β-OHC ; 4β-hydroxycholesterol ; 5β ; 6β-epoxy ; 5β ; 6β
- 刊名：Redox Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：9
- 期：Complete
- 页码：296-305
- 全文大小：2235 K
文摘
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Dietary fatty acids or cholesterol induce specific liver histological alterations.
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A lipidomic approach allows the identification of steatotic oxysterol fingerprint.
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FA and Ch interaction is a potential pathogenic mechanism for steatohepatitis.