Persistent GABAA/C responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons
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- 作者：D. Chesnoy-Marchais dominique.chesnoy@inserm.fr" class="auth_mail" title="E-mail the corresponding author dominique.chesnoy@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALS ; amyotrophic lateral sclerosis ; Bicu ; bicuculline methochloride ; ECl ; chloride equilibrium potential ; D-AP-5 ; d-2-amino-5-phosphonovaleric acid ; GABA ; gamma-aminobutyric acid ; EGTA ; ethylene glycol-bis(2-aminoethylether)-N ; N ; N&prime ; N&prime ; -tetraacetic acid ; HEPES ; (2-hydroxyethyl)piperazine-1-ethanesulfonic acid ; HM ; hypoglossal motoneuron ; KA ; kynurenic acid sodium salt ; PB ; pentobarbital sodium ; SR or SR95531 ; 2-(3-carboxypropyl)-3-amino-6-(4methoxyphenyl)pyridazinium bromide or gabazin
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：330
- 期：Complete
- 页码：191-204
- 全文大小：1463 K
文摘
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Gabazine activates a bicuculline-resistant and TPMPA-sensitive Cl− current in HMs.
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Pentobarbital potentiates this response whereas allopregnanolone and midazolam do not.
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The receptors involved are likely hybrid GABA receptors including ρ and γ subunits.
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20">β amino acids activate strychnine-resistant, TPMPA-sensitive, sustained Cl− currents.
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25">The resulting sustained inhibition should contribute to neuroprotection by taurine.