Reproductive steroid receptors and actions in the locus coeruleus of male macaques: Part of an aggression circuit?
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- 作者：Cynthia L. Betheaa ; b ; c ; betheac@ohsu.edu" class="auth_mail" title="E-mail the corresponding author ; Yelena Belikovaa ; Kenny Phua ; Grace Mammerellaa
- 关键词：Male macaque ; Androgen receptors ; Estrogen receptors ; Tyrosine hydroxylase ; Dopamine-β-hydroxylase ; Corticotropin releasing hormone
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：210-222
- 全文大小：2348 K
文摘
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NE neurons contain ERα and ERβ, but not AR.
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Androgens increase tyrosine hydroxylase (TH) in dendrites of locus coeruleus (LC).
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Androgens increase dopamine-β-hydroxylase (DBH) axon density in the dorsal raphe.
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Metabolism of T to estrogen (E) increases CRF axon density in the LC.
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Androgens increase androgen receptor (AR) expression in the LC, but not ERα or ERβ.