Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner
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- 作者：Lexiao Li ; Pamela Saliba ; Stefan Reischl ; Hugo H. Marti ; Reiner Kunze ; reiner.kunze@physiologie.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：BBB ; blood-brain barrier ; GFAP ; glial fibrillary acidic protein ; HIF ; hypoxia inducible factor ; KO ; knockout ; MCAO ; middle cerebral artery occlusion ; PHD ; prolyl 4-hydroxylase domain protein ; ROI ; region of interest ; WT ; wild-type ; SVZ ; subventricular zone ; VEGF ; vascular endothelial growth factor
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：221-235
- 全文大小：6336 K
文摘
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Neuronal loss of PHD2 improves histological and functional stroke recovery.
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PHD2 KO increases vascular density and reduces inflammatory responses post-stroke.
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Post-stroke recovery and angiogenesis are dependent on the presence of neuronal HIF.