Tryptophan hydroxylase type 2 variants modulate severity and outcome of addictive behaviors in Parkinson's disease
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- 作者：Roberto Ciliaa ; roberto.cilia@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Roberta Benfanteb ; c ; 1 ; Rosanna Asseltad ; e ; 1 ; Laura Marabinif ; Emanuele Ceredag ; Chiara Siria ; Gianni Pezzolia ; Stefano Goldwurma ; 2 ; Diego Fornasarib ; c ; 2
- 关键词：Parkinson disease ; Impulse control disorders ; Genetics ; Addiction ; Serotonin
- 刊名：Parkinsonism & Related Disorders
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：29
- 期：Complete
- 页码：96-103
- 全文大小：287 K
文摘
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TPH2 genotype (mainly rs1352250) and TPH2 GGA haplotype are associated with increased severity of addictive symptoms.
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TPH2 variants interact with the BDNF to modulate the risk of abnormal behaviors.
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TPH2 genotype and haplotype are associated with reduced remission rate after 1 year and at the last follow-up (mean 5 years).
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TPH2 genotype influences long-term behavioral remission more than dopaminergic therapy adjustment.