Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat
文摘
HyperT blocks suckling-induced PRL release and advances the prepartum PRL surge. HyperT elevated hypothalamic TH mRNA and p-TH on late pregnancy and early lactation. PRLR, STAT5, CIS, PRA and B also increased on late pregnancy and/or early lactation. The altered PRL signaling and PRs may induce elevated TH expression and activation. This elevates dopaminergic tone on lactation, blunting PRL release and litter growth.