The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation
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- 作者：Julian Wampflera ; b ; julianwampfler@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Elena A. Federzonic ; federzon@scripps.edu" class="auth_mail" title="E-mail the corresponding author ; Bruce E. Torbettc ; betorbet@scripps.edu" class="auth_mail" title="E-mail the corresponding author ; Martin F. Feyd ; martin.fey@insel.ch" class="auth_mail" title="E-mail the corresponding author ; Mario P. Tschana ; b ; mario.tschan@pathology.unibe.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABL1 ; ABL proto-oncogene 1 ; AML ; acute myeloid leukemia ; APL ; acute promyelocytic leukemia ; ATRA ; all-trans retinoic acid ; CDKN1A ; cyclin-dependent kinase inhibitor 1A ; DND1 ; DEAD END 1 ; FAB ; French American British classification ; FBS ; fetal bovine serum ; G-CSF ; granulocyte colony stimulating factor ; G-CSF-R ; granulocyte colony stimulating factor receptor ; HMBS ; hydroxymethylbilane synthase ; HOVON/SAKK ; Dutch&ndash ; Belgian Hematology&ndash ; Oncology/Swiss Group for Clinical Cancer Research Coope
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：96-102
- 全文大小：1274 K
文摘
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RBM38 and DND1 expression is attenuated in primary AML patients.
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Normal and leukemic neutrophil differentiation induces RBM38 and DND1 expression.
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New function for the RNA binding proteins RBM38 and DND1 in APL differentiation.