Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms
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- 作者：Piotr Chruściela ; 1 ; Amirhossein Sahebkarb ; c ; 1 ; Magdalena Rembek-Wieliczkoa ; j ; Maria-Corina Serband ; e ; Sorin Ursoniuf ; Dimitri P. Mikhailidisg ; Steven R. Jonesh ; Svetlana Mosteorui ; Michael J. Blahah ; Seth S. Martinh ; Jacek Rysza ; j ; Peter P. Tothh ; k ; Gregory Y.H. Lipl ; Michael J. Pencinam ; Kausik K. Rayn ; Maciej Banacha ; j ; maciejbanach@aol.co.uk" class="auth_mail" title="E-mail the corresponding author ; Lipid ; Blood Pressure Meta-analysis Collaboration (LBPMC) Group
- 关键词：Adiponectin ; Statins ; Hydroxymethylglutaryl-CoA reductase inhibitors ; Meta-analysis
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：253
- 期：Complete
- 页码：194-208
- 全文大小：5525 K
文摘
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The effect of statin therapy on plasma adiponectin levels has not been conclusively studied.
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The analysis shows a significant increase in plasma adiponectin levels after statin therapy (WMD: +0.57 μg/mL).
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The meta-analysis confirmed that statins may have an important impact on the adiponectin levels.
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The pleiotropic adiponectin-elevating effect of statins might explain the benefits of statins in reducing the CV risk.