刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:2017
出版时间:January 2017
年:2017
卷:165
期:part_PA
页码:145-150
全文大小:1170 K
卷排序:165
文摘
AME is a hypertensive disorder owing to 11ßHSD2 deficiency. More than 40 mutations in the HSD11B2 gene causing AME have been identified. Chronic hypertension in AME leads to the early development of end organ damage. Spironolactone treatment of AME normalizes blood pressure and improves growth. Renal transplantation of patients with AME and renal failure led to cure of AME.