Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: Structure–function studies and inhibitor development

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• 作者：Yanyan Hong^a ; Shiuan Chen ; ^a ; ^{schen@coh.org"" rel=""nofollow}
• 关键词：Aromatase ; Estrone sulfatase ; 17&#x3b2 ; -Hydroxysteroid dehydrogenase ; Crystal structure ; Inhibitor ; Breast cancer
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2011
• 出版时间：4 July 2011
• 年：2011
• 卷：340
• 期：2
• 页码：120-126
• 全文大小：1193 K

文摘

Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase type 1 are involved in the key steps of 17β-estradiol biosynthesis. Structure–function studies of aromatase, estrone sulfatase and 17β-hydroxysteroid dehydrogenase type 1 are important to evaluate the molecular basis of the interaction between these enzymes and their inhibitors. Selective and potent inhibitors of the three enzymes have been developed as antiproliferative agents in hormone-dependent breast carcinoma. New treatment strategies for hormone-dependent breast cancer are discussed.