Preparation and spectroscopic characterization of methoxy poly(ethylene glycol)-grafted water-soluble chitosan

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• 作者：Young-Il Jeong ; Don-Gon Kim ; Mi-Kyeong Jang ; Jaw-Woon Nah
• 关键词：Water-soluble chitosan ; Poly(ethylene glycol) ; Aqueous solubility ; Organic solvent solubility ; Graft copolymer
• 刊名：Carbohydrate Research
• 出版年：2008
• 出版时间：4 February 2008
• 年：2008
• 卷：343
• 期：2
• 页码：282-289
• 全文大小：1114 K

文摘

The object of this study was to test the solubility of a methoxy poly(ethylene glycol) (MPEG)-grafted chitosan copolymer in organic solvents and aqueous solution. Water-soluble chitosan with low molecular weight (LMWSC) was used in a PEG-graft copolymerization. The MPEG was conjugated to chitosan using 4-dicyclohexylcarbodimide (DCC), and N-hydroxysuccimide (NHS). Introduction of PEG was confirmed by ¹H and ¹³C NMR spectroscopy and FT-IR spectroscopy. The degree of substitution (DS) of MPEG into chitosan was calculated from ¹H NMR data and also by estimating the molecular weight (MW) using gel permeation chromatography (GPC). The DS values obtained from ¹H NMR spectroscopy and GPC were similar, indicating that MPEG-grafted LMWSC was synthesized and properly characterized. Furthermore, the introduction of PEG into chitosan increases the solubility in aqueous solutions over a range of pH values (4.0–11.0) and organic solvents such as DMF, DMSO, ethanol, and acetone.