Synthesis of 1,7-dimethoxy-2-hydroxyxanthone, a natural product with potential activity on erectile dysfunction

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• 作者：Wen-Jing Liu^a ; De-Sheng Mei^b ; ^{meids@mail.shcnc.ac.cn} ; Wen-Hu Duan^a ; ^b ; ^{whduan@mail.shcnc.ac.cn}
• 关键词：1 ; 7-Dimethoxy-2-hydroxyxanthone ; Erectile dysfunction ; Synthesis ; Copper-catalyzed coupling reaction
• 刊名：Chinese Chemical Letters
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：24
• 期：6
• 页码：515-517
• 全文大小：253 K

文摘

The natural product, 1,7-dimethoxy-2-hydroxyxanthone (1), isolated from Securidaca inappendiculate Hassk, has a potential in the treatment of erectile dysfunction due to its significant relaxation activity on rabbit Corpus cavernosum. However, the isolation of compound 1 is problematic because of its high similarity in structure to its analogs. In this paper, the first synthesis of 1 was reported featuring two key reactions: a copper-catalyzed coupling reaction and an intramolecular cyclization.