A Meta-analysis for the Diagnostic Performance of Transient Elastography for Clinically Significant Portal Hypertension
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- 作者：Myung-Won You&lowast ; ; Kyung Won Kim&lowast ; ; &dagger ; ; medimash@gmail.com ; Junhee Pyo&Dagger ; ; Jimi Huh&lowast ; ; Hyoung Jung Kim&lowast ; ; &dagger ; ; So Jung Lee&lowast ; ; &dagger ; ; Seong Ho Park&lowast ;
- 关键词：Transient elastography ; Fibroscan ; Portal hypertension ; Liver stiffness measurement ; Chronic liver disease
- 刊名：Ultrasound in Medicine & Biology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：43
- 期：1
- 页码：59-68
- 全文大小：1197 K
- 卷排序：43
文摘
We aimed to evaluate the correlation between liver stiffness measurement using transient elastography (TE-LSM) and hepatic venous pressure gradient and the diagnostic performance of TE-LSM in assessing clinically significant portal hypertension through meta-analysis. Eleven studies were included from thorough literature research and selection processes. The summary correlation coefficient was 0.783 (95% confidence interval [CI], 0.737–0.823). Summary sensitivity, specificity and area under the hierarchical summary receiver operating characteristic curve (AUC) were 87.5% (95% CI, 75.8–93.9%), 85.3 % (95% CI, 76.9–90.9%) and 0.9, respectively. The subgroup with low cut-off values of 13.6–18 kPa had better summary estimates (sensitivity 91.2%, specificity 81.3% and partial AUC 0.921) than the subgroup with high cut-off values of 21–25 kPa (sensitivity 71.2%, specificity 90.9% and partial AUC 0.769). In summary, TE-LSM correlated well with hepatic venous pressure gradient and represented good diagnostic performance in diagnosing clinically significant portal hypertension. For use as a sensitive screening tool, we propose using low cut-off values of 13.6–18 kPa in TE-LSM.