EPA- and DHA-derived resolvins' actions in inflammatory bowel disease

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• 作者：Raquel Cristina Schwanke^a ; Rodrigo Marcon^a ; Allisson Freire Bento^a ; Joã ; o B. Calixto^a ; ^b ; ^{joao.calixto@cienp.org.br" class="auth_mail" title="E-mail the corresponding author} ; ^{calixto@farmaco.ufsc.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：(RvD) ; D-series resolvin ; (RvE) ; E-series resolvin ; (EPA) ; eicosapentaenoic acid ; (DHA) ; docosahexaenoic acid ; (RvE1) ; 18S-R-resolvin E1 ; (RvE2) ; 18S-R-resolvin E2 ; (RvE3) ; 17 ; 18-diHEPE-resolvin E3 ; (8S-RvE3) ; 18R ; 18S-dihydroxy-5Z ; 8Z ; 11Z ; 13E ; 15EEPE ; (18R-RvE3) ; 17 ; 18R-dihydroxy-5Z ; 8Z ; 11Z ; 13E ; 15E-EPE ; (18S-RvE1) ; 18S-resolvin E1 ; (Maresin ; MaR1) ; macrophage mediator in resolving inflammation ; (AT-RvD1&ndash ; D4) ; (aspirin-triggered) ; resolvins D1&ndash ; D4 ; (ALX) ; lipoxin A4 receptor ; (BOC-1) ; N-t-
• 刊名：European Journal of Pharmacology
• 出版年：2016
• 出版时间：15 August 2016
• 年：2016
• 卷：785
• 期：Complete
• 页码：156-164
• 全文大小：509 K

文摘

Inflammatory bowel diseases are chronic diseases divided into two major forms, ulcerative colitis and Crohn's disease, which are both associated with a chronic inflammatory condition of the gastrointestinal tract. Recent studies have shown that the resolution of inflammatory conditions is a biosynthetically active process where new pro-resolution lipid mediators derived from omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), such as E- and D-series resolvins, protectins, and macrophage mediator in resolving inflammation (maresins), have potent anti-inflammatory activity and serve as specialised mediators that play an important role in the resolution of inflammation. Recent studies have also shown the role of resolvins in referred hyperalgesia associated with different inflammatory processes, such as the visceral pain caused by inflammatory bowel disease. There are many reports describing the principal effects of EPA- and DHA-derived mediators in experimental models of inflammatory bowel diseases. This review focuses on the recent studies on the important role played by pro-resolution lipid mediators in controlling the inflammatory process associated with inflammatory bowel diseases.