Modulating the expression of genes associated with hepatic lipid metabolism, lipoperoxidation and inflammation by cocoa, cocoa extract and cocoa flavanols related to hepatic steatosis induced by a hypercaloric diet
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- 作者：Griselda M. Rabadá ; n-Chá ; veza ; Angel Miliar Garciab ; Norma Paniagua Castroc ; Gerardo Escalona Cardosoc ; Lucia Quevedo-Coronac ; Elba Reyes-Maldonadod ; Marí ; a Eugenia Jaramillo-Floresa ; jaramillo_flores@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cocoa ; flavanols ; hepatic lipid metabolism ; inflammation ; gene expression ; proinflammatory cytokines ; lipogenesis
- 刊名：Food Research International
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：89
- 期：part_P2
- 页码：937-945
- 全文大小：998 K
文摘
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Cocoa flavanols decrease intra-abdominal fat mass accumulation and liver weight.
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CD36, PPARγ downregulation by flavanols contributes to decrease fatty acid uptake
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ACC downregulation by flavanols contributes to decrease hepatic de novo lipogenesis
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PPARα, PGC1α, SIRT1 upregulation by flavanols diminish hepatic triglyceride content
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Cocoa flavanols reduce liver inflammation by downregulation of TNF-α, Il-6 and TLR4