5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation

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• 作者：Reut Levi-Rosenzvig^a ; ^b ; Andreas M. Beyer^c ; ^d ; Joseph Hockenberry^c ; Rotem Shelly Ben-Shushan^a ; Dimitry Chuyun^e ; Shahar Atiya^a ; ^b ; Snait Tamir^a ; ^b ; David D. Gutterman^c ; Andrea Szuchman-Sapir^a ; ^b ; ^{andreas@migal.org.il}
• 关键词：Endothelium-dependent hyperpolarization factor ; Vasodilation ; 5 ; 6-DHTL ; Microvessels ; Lactones
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：87-94
• 全文大小：625 K
• 卷排序：103

文摘

5,6-δ DHTL is a potential EDHF, that dilates microvessels. 5,6-δ-DHTL initiates intracellular Ca2+ influx through channels other than TRPV4. 5,6-δ-DHTL initiates Ca2+ released from the ER. 5,6-δ-DHTL mechanism of action is mainly NO-independent. 5,6-δ-DHTL-induced hyperpolarization of ECs.