Contribution of large-sized primary sensory neuronal sensitization to mechanical allodynia by upregulation of hyperpolarization-activated cyclic nucleotide gated channels via cyclooxygenase 1 cascade

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• 作者：Wei Sun^a ; ^b ; ¹ ; Fei Yang^a ; ^b ; ¹ ; Yan Wang^a ; ^b ; ¹ ; Han Fu^a ; ^b ; Yan Yang^a ; ^b ; Chun-Li Li^a ; ^b ; Xiao-Liang Wang^a ; ^b ; Qing Lin^d ; ^{qilin@uta.edu} ; Jun Chen^a ; ^b ; ^c ; ^{junchen@fmmu.edu.cn}
• 关键词：Bee venom ; Large-sized DRG neurons ; Hyperexcitability ; Hyperpolarization-activated cation channel ; Cyclooxygenases 1 ; Prostaglandin E2
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：217-230
• 全文大小：3498 K
• 卷排序：113

文摘

Large-sized DRG neurons (66%) show firing pattern switch and hyperexcitability in peripheral inflammatory pain state. The hyperexcitability and firing pattern switch are likely to be caused by increase in h current. Increased h current is mediated by overexpression of HCN1/2 proteins via COX-1/PGE2 cascade in large-sized DRG neurons. HCN channel-mediated hyperexcitability of large-sized DRG neurons contributes to mechanical allodynia.