The author addresses the question whether the moment of emergence of hypochondria in the clinic of cancer is decisive for the patient as well as for the psychotherapist. Hypochondria is thus perceived, on the one hand, concerning cancer, as an opportunity for the body to suffer from something else than cancer, but also as an attempt to sacrifice a part of the body in order to keep the rest of it alive, and on the other hand, more generally as an attempt to restore autoerotic defaults, thanks to the constitution of erotogenic zones around the hypochondriac organ. The author puts forward the hypothesis that hypochondria could be, in the clinical encounter with cancer patients, a means of apo-destruction of the thought.