NMDA receptor hypofunction and the thalamus in schizophrenia
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- 作者：Zoran Vukadinovic ; zvukadi@gmail.com" class="auth_mail
- 关键词：NMDAR ; Psychosis ; Higher order thalamic nuclei ; Sensorimotor gating
- 刊名：Physiology and Behavior
- 出版年：28 May 2014
- 年：2014
- 卷：131
- 期：Complete
- 页码：156-159
- 全文大小：263 K
文摘
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Higher order (HO) thalamic relays transmit copies of cortical motor instructions.
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HO thalamic nuclei are affected in schizophrenia.
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Schizophrenia involves a failure of internal motor monitoring mechanisms.
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NMDAR hypofunction in schizophrenia may impair the function of HO nuclei by attenuating driver inputs from the cortex.