- 作者：Yobi Doudou ; Piarroux Renaud ; L'Ollivier Coralie ; Franck Jacqueline ; Situakibanza Hypolite ; Muhindo Hypolite ; Mitashi Patrick ; Inoc锚ncio da Luz Raquel Andreia ; Marc Van Sprundel ; Boelaert Marleen ; Jean-Pierre Van Geertruyden ; Lutumba Pascal
- 关键词：Seroprevalence ; Toxoplasmosis ; Pregnant women ; Kinshasa
- 刊名：Asian Pacific Journal of Tropical Biomedicine
- 出版年：January, 2014
- 年：2014
- 卷：4
- 期：1
- 页码：69-74
- 全文大小：307 K
Objective
To determine the seroprevalence of toxoplasmosis in pregnant women, as well as the proportion of acutely infected and risk factors in the Democratic Republic of Congo.Methods
Thirty maternities in Kinshasa were randomly selected and women attending antenatal consultation were invited to participate. They were interviewed with a structured questionnaire about known risk factors (age, meat consumption, contact with soil, and presence of cat) and a venous blood sample was taken. Sera were analysed for total immunoglobulins (Ig) by VIDAS Toxo Competition using Enzyme Linked Fluorescent Assay. IgM was determined by VIDIA Toxo IgM and IgG avidity by VIDAS Toxo IgG avidity.
Results
A total of 781 women were included. Median age was 28 years old (IQR: 8.5). And 627 women (80.3%; 95% CI: 77.5-83.1) were found to be positive to total Ig and 17 out of 387 (4.4%; 95% CI: 2.3-6.4) were positive to IgM. IgG avidity was low for 2 (11.8%) women, intermediate for 2 (11.8%) and high for 13 women (76.4%). There was no statistically significant association between Toxoplasma gondii infection and any risk factors assessed.
Conclusion
In Kinshasa, toxoplasmosis endemicity is highly prevalent. One woman out of twenty five had a recent toxoplasmosis infection and 20% were not protected against primo-infection, indicating a need for measures to prevent and control toxoplasmosis during pregnancy.