Chronic cerebral hypoperfusion induces long-lasting cognitive deficits accompanied by long-term hippocampal silent synapses increase in rats
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- 作者：Zhiqiang Wanga ; b ; Jin Fanb ; Jian Wangb ; Yuxia Lib ; Dan Duanb ; Guo Dub ; Qingsong Wangb ; wqs832001@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CCH ; chronic cerebral hypoperfusion ; BCCAO ; bilateral common carotid artery occlusion ; MWM ; Morris water maze ; ORT ; object recognition task ; DI ; discrimination index ; GluR2 ; AMPA receptor 2 ; NMDAR ; N-methyl-d-aspartate receptor ; NR1 ; NMDAR1 ; VCI ; vascular cognitive impairment ; AD ; Alzheimer&rsquo ; s disease ; CBF ; cerebral blood flow ; PICK1 ; protein interacting with C kinase 1
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：243-252
- 全文大小：2226 K
文摘
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Chronic cerebral hypoperfusion causes long-lasting cognitive deficit.
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Silent synapses exist in the adult brain.
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Chronic brain hypoperfusion induces long-term silent synapses increase in CA1 of rat.