BCL11B regulates sutural patency in the mouse craniofacial skeleton
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- 作者：Kateryna Kyrylkovaa ; 1 ; Urszula T. Iwaniecb ; Kenneth A. Philbricka ; Mark Leida ; c ; mark.leid@oregonstate.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BCL11B/CTIP2 ; Craniofacial development ; Craniosynostosis ; Midfacial hypoplasia ; Fgfr2c ; Runx2 ; Twist1
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：415
- 期：2
- 页码：251-260
- 全文大小：4918 K
文摘
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Bcl11bncc−/− and Bcl11b−/− mice exhibit severe cranial and facial synostoses.
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BCL11B is expressed in developing craniofacial osteogenic and sutural mesenchyme.
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BCL11B restricts premature osteoblast differentiation and mineralization of the skull.
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BCL11B prevents ectopic expression of Fgfr2c and Runx2 in sutures.
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BCL11B maintains expression of Twist1 in sutures.