Leptin receptor-positive and leptin receptor-negative proopiomelanocortin neurons innervate an identical set of brain structures
详细信息 查看全文
- 作者：Leandro B. Lima ; Martin Metzger ; Isadora C. Furigo ; J. Donato Jr. ; jdonato@icb.usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：3V ; 3rd ventricle ; ac ; anterior commissure ; AgRP ; agouti-related peptide ; Aq ; aqueduct ; Arc ; arcuate hypothalamic nucleus ; CC ; central canal ; ChaT ; choline acetyltransferase ; ChAT-ir ; choline acetyltransferase-immunoreactivity ; D3V ; dorsal 3rd ventricle ; DM ; dorsomedial hypothalamic nucleus ; DMC ; dorsomedial hypothalamic nucleus ; compact part ; DMD ; dorsomedial hypothalamic nucleus ; dorsal part ; DMV ; dorsomedial hypothalamic nucleus ; ventral part ; DRL ; dorsal raphe nucleus ; lateral part ; IML ; int
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1646
- 期：Complete
- 页码：366-376
- 全文大小：13687 K
文摘
- •
Approximately 80% of Arc POMC neurons express the leptin receptor (POMC/LepR+ cells)
- •
An elevated degree of co-localization was observed in all brain regions analyzed
- •
No brain nuclei contained exclusively axonal terminals from POMC/LepR− neurons
- •
POMC/LepR+ and POMC/LepR− cells may contact distinct neurons in some target nuclei.