NTPDase3 is the a membrane-bound ecto-enzyme which hydrolyzes extracellular ATP.
Developmental expression of NTPDase3 was analyzed in female rat brain at several postnatal ages (PD7-PD90).
Faint NTPDase3-imunoreactivity (ir) was observed at PD7 and gradually increased in PD15 and PD20 at clusters of hypothalamic neurons.
NTPDase3-ir fibers were first observed at PD20.
NTPDase3- ir fiber density and the varicose appearance increased until the adulthood.