Maternal programming of offspring hypothalamic-pituitary-interrenal axis in wild sockeye salmon (Oncorhynchus nerka)

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• 作者：N.M. Sopinka^a ; ^{sopinka@uwindsor.ca} ; J.D. Jeffrey^b ; ¹ ; N.J. Burnett^a ; ^c ; D.A. Patterson^d ; K.M. Gilmour^b ; S.G. Hinch^a
• 关键词：ACTH ; adrenocorticotropic hormone ; ANOVA ; analysis of variance ; ANCOVA ; analysis of covariance ; cAMP ; 30&ndash ; 50-cyclic adenosine monophosphate ; cDNA ; complementary deoxyribonucleic acid ; CRF ; corticotropin-releasing factor ; DFO ; Department of Fisheries and Oceans ; DNA ; deoxyribonucleic acid ; dNTP ; deoxynucleotide ; EIA ; enzyme immunoassay ; EST ; expressed sequence tags ; GC ; glucocorticoid ; GR ; glucocorticoid receptor ; HPA ; hypothalamic&ndash ; pituitary&ndash ; adrenal ; HPI ; hypothalamic&ndash ; pitui
• 刊名：General and Comparative Endocrinology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：242
• 期：Complete
• 页码：30-37
• 全文大小：919 K
• 卷排序：242

文摘

Functioning of the progeny HPI axis is influenced by maternal stressor exposure. The cortisol response of progeny reared from stressed mothers was attenuated. These progeny also had higher constitutive mRNA abundance of MC2R, StAR and GR2.