Generation of 5-HT2CRYFP mouse line revealed 40% of hypothalamic POMC neurons co-express 5-HT2CRs in male and female mice.
Pomc expressed exclusively within 5-HT2CR cells modulates energy intake and insulin sensitivity in male and female mice.
An unexpected sex difference in physical activity and energy expenditure is modulated by hypothalamic Pomc.
Pomc expressed exclusively within 5-HT2CR cells differentially impacts body weight accumulation in male and female mice.