Magnocellular hypothalamic system and its interaction with the hypothalamo-pituitary-adrenal axis
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- 作者：Elena V. Sivukhina ; Gustav F. Jirikowski ; Gustav.Jirikowski@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACTH ; adrenocorticotropic hormone ; CBG ; corticosteroid-binding globulin ; CHF ; chronic heart failure ; CRH ; corticotropin-releasing hormone ; GCs ; glucocorticoids ; HNS ; hypothalamo-neurohypophyseal system ; HPA axis ; hypothalamo-pituitary&ndash ; adrenal axis ; OT ; oxytocin ; PVN ; paraventricular nucleus ; SON ; supraoptic nucleus ; VP ; vasopressin
- 刊名：Steroids
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：21-28
- 全文大小：3317 K
文摘
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The hypothalamo-neurohypophyseal system (HNS) is controlled by adrenal and gonadal steroids.
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Magnocellular vasopressin and oxytocin are regulators of hypophyseal functions.
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The hypothalamus pituitary adrenal (HPA) axis interacts with the HNS.
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Central and systemic response to the chronic stress is in part mediated by adrenal steroids.
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Chronic ailments including cardiac conditions or neurodegenerative diseases may be linked to altered HNS–HPA interaction.