Deep hypothermia-enhanced autophagy protects PC12 cells against oxygen glucose deprivation via a mitochondrial pathway
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- 作者：Dang Tanga ; Cheng Wangb ; Yongjun Gaoa ; Jun Pua ; Jiang Longc ; Wei Xua ; 1017469868@qq.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DHCA ; deep hypothermic circulatory arrest ; DH ; deep hypothermia ; OGD ; oxygen glucose deprivation ; I/R ; ischemia/reperfusion ; CytC ; cytochrome c ; PARP ; poly-ADP-ribose polymerase ; PC12 ; a cell line derived from a pheochromocytoma of the rat adrenal medulla ; MMP ; mitochondrial membrane potenti ; 3-MA ; 3-methyladenine ; LC3 ; Microtubule-associated protein light chain 3
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：632
- 期：Complete
- 页码：79-85
- 全文大小：3474 K
文摘
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Deep hypothermia protects against OGD-induced cell injury.
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Neuroprotective effects of deep hypothermia are associated with suppressing mitochondrial apoptotic pathway.
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Deep hypothermia-enhanced autophagy plays a protective role via a mitochondrial pathway.