Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease

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• 作者：Maud Gratuze^a ; ^b ; Noura B. El Khoury^a ; ^b ; André ; anne Turgeon^a ; ^b ; Carl Julien^b ; Franç ; ois Marcouiller^a ; ^b ; Franç ; oise Morin^b ; Robert A. Whittington^c ; André ; Marette^d ; Fré ; dé ; ric Calon^b ; ^e ; Emmanuel Planel^a ; ^b ; ^{emmanuel@planel.org}
• 关键词：Alzheimer's disease ; Diabetes mellitus ; ob/ob mice ; Tau hyperphosphorylation ; hippocampus ; Kinase ; Phosphatase ; Hypothermia ; Temperature ; Thermoregulation ; Leptin ; Caffeine
• 刊名：Neurobiology of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：98
• 期：Complete
• 页码：1-8
• 全文大小：1016 K
• 卷排序：98

文摘

Type 2 diabetes is an important risk factor of Alzheimer's disease (AD). The ob/ob mouse model of Type 2 diabetes exhibit tau hyperphosphorylation in hippocampus. Hypothermia is the leading cause of tau hyperphosphorylation. Caffeine is associated with tau hyperphosphorylation by promoting deeper hypothermia. Impaired thermoregulation might be important in linking diabetes and AD.