Rats were fed control and alcohol diets±S-Adenosylmethionine (SAM) for 5 weeks.
10">SAM prevented alcohol-induced liver hypoxia.
15">SAM normalized mitochondrial respiration in alcohol-fed rats.
SAM normalized sensitivity to undergo the mitochondrial permeability transition in alcohol-fed rats.
SAM normalized nitric oxide-mediated respiratory inhibition in alcohol-fed rats.