Induction of integrin β3 by sustained ERK activity promotes the invasiveness of TGFβ-induced mesenchymal tumor cells
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- 作者：Soon-Ki Hong ; Jeong-Rak Park ; Ok-Seon Kwon ; Keun-Tae Kim ; Gab-Yong Bae ; gabyong977@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hyuk-Jin Cha ; hjcha@sogang.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Integrin β3 ; ERK1/2 ; TGFβ ; Epithelial&ndash ; mesenchymal transition (EMT)
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：376
- 期：2
- 页码：339-346
- 全文大小：2383 K
文摘
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Integrin β3 by TGFβ is increased in Smad-independent manner.
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Integrin β3 by TGFβ is upregulated by MEK/ERK in mesenchymal-type cancer cells.
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Depletion of integrin β3 loses pro-metastatic properties.