Metabolic biomarkers for non-alcoholic fatty liver disease induced by high-fat diet: In vivo magnetic resonance spectroscopy of hyperpolarized [1-¹³C] pyruvate

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• 作者：Chung-Man Moon^a ; Chang-Hyun Oh^b ; Kyu-Youn Ahn^c ; Jun-Seok Yang^d ; Jae-Young Kim^d ; Sang-Soo Shin^d ; Hyo-Soon Lim^d ; Sook-Hee Heo^d ; Hyun-Ju Seon^d ; Jin-Woong Kim^d ; Gwang-Woo Jeong^a ; ^d ; ^{gwjeong@jnu.ac.kr}
• 关键词：Hyperpolarized 13C ; Dynamic nuclear polarization (DNP) ; Non-alcoholic fatty liver disease (NAFLD) ; High-fat diet
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：482
• 期：1
• 页码：112-119
• 全文大小：1801 K
• 卷排序：482

文摘

Hyperpolarized 13C-alanine and lactate are noninvasive biomarkers on hepatosteatosis. During the course of HFD feeding, 13C-alanine and lactate were increased in HFD-rats. Hyperpolarized 13C dynamic MRS will be helpful to monitor the progression of NAFLD.