α-Isocubebenol alleviates scopolamine-induced cognitive impairment by repressing acetylcholinesterase activity

详细信息    查看全文

• 作者：Sung Hwa Song^a ; ¹ ; Seong Mi Choi^b ; ¹ ; Ji Eun Kim^a ; Ji Eun Sung^a ; Hyun Ah Lee^a ; Yung Hyun Choi^c ; Chang Joon Bae^d ; Young Whan Choi^b ; ^{ywchoi@pusan.ac.kr} ; Dae Youn Hwang^a ; ^{dyhwang@pusan.ac.kr}
• 关键词：α-iso-cubebenol ; Cognitive impairment ; Scopolamine ; Acetylcholinesterase
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：638
• 期：Complete
• 页码：121-128
• 全文大小：2689 K
• 卷排序：638

文摘

ICO pre-intake may protect against the long-term memory defect induced by SP injection. ICO pretreatment could induce suppression of the AChE activity in the hippocampus of ICR mice. The increased ERK phosphorylation induced by ICO pretreatment could activate neuronal cell survival signaling pathways in the hippocampus. Our findings indicate the potential of ICO for use in the prevention and treatment of AD in humans.