文摘
Synthesis of Fmoc-pyrazole amino acids for the first time. Synthesis of Pyrazole-arginine based ultra short peptidomimetics using solid phase peptide synthesis. Ultra short peptidomimetics showed broad-spectrum of antimicrobial activity including MRSA, VREF, and MDRPA. Ultra short peptidomimetics also displayed potent anti-biofilm activity. Mechanistic studies including inner membrane, outer membrane permeability, membrane depolarization and TEM images.