文摘
Fe prochelator BHAPI was examined for protection against catecholamine cardiotoxity. BHAPI has no affinity for iron ions until it is activated to active chelator HAPI. Catecholamines, as a source of ROS, induced conversion of BHAPI into HAPI. BHAPI and HAPI decrease ROS formation induced by catecholamines. BHAPI and HAPI protect H9c2 cells against oxidative injury induced by catecholamines.