Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts
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- 作者：Antonio Gonzá ; lez-Sarrí ; as
- 关键词：AUCall ; area under the plasma concentration-time curve from the time of dosing to the time of the last observation ; BMI ; body mass index ; Cmax ; maximum plasma concentration ; EA ; ellagic acid ; ET ; ellagitannin ; MRTlast ; mean residence time for a molecule to reside in the body calculated from the time of dosing to the time of the last measurable concentration ; PE-1 ; pomegranate extract with low punicalagin/EA ratio ; PE-2 ; pomegranate extrat with high punicalagin/EA ratio ; Uro-A ; urolithin A ; Uro-B
- 刊名：Journal of Functional Foods
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：19
- 期：part_PA
- 页码：225-235
- 全文大小：590 K
文摘
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- <p id="p0010">Very high free ellagic acid (EA) intake does not enhance EA bioavailability.p>
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- <p id="p0015">pH, ellagitannin precursor and proteins are critical for EA bioavailability.p>
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- <p id="p0020">Plasma EA pharmacokinetics show high interindividual variability.p>
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- <p id="p0025">Free EA rarely exceeds 100 nM in human plasma but it is higher than previously thought.p>
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- <p id="p0030">We provide useful data to design in vitro assays using physiological concentrations.p>