Synthesis, structural study and biological activity of new derivatives of chrysin containing a 2-mercaptopyridyl or 5-(trifluoromethyl)-2-mercaptopyridyl fragments
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- 作者：Alejandro Valdez-Calderó ; na ; Simplicio Gonzá ; lez-Montiela ; gmontiel@uaeh.edu.mx" class="auth_mail" title="E-mail the corresponding author ; Diego Martí ; nez-Oterob ; Ataulfo Martí ; nez-Torresc ; José ; Manuel Vá ; squez-Pé ; reza ; d ; Carlos Molina-Verac ; J. Martí ; n Torres-Valenciaa ; jmartin@uaeh.edu.mx" class="auth_mail" title="E-mail the corresponding author ; José ; G. Alvarado-Rodrí ; gueza ; Julian Cruz-Borbollaa
- 关键词：Chrysin derivatives ; 2-mercaptopyridinyl fragments ; Crystal structure ; Theoretical calculations ; Hirshfeld surface ; C. elegans
- 刊名：Journal of Molecular Structure
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：1110
- 期：Complete
- 页码：196-207
- 全文大小：1947 K
文摘
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New chrysin derivatives containing 2-mercaptopyridine were prepared.
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Molecular and crystal structure analyses are presented.
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Intermolecular contacts were supported by QTAIM and Hirshfeld surface analyses.
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Compounds boldFont">2e, boldFont">3b and boldFont">3c inhibited larval development of Caenorhabiditis elegans.