GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium
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- 作者：Jia Huo&dagger ; ; Xiao-Ling Zhu&dagger ; ; Rui Ma ; Hai-Long Dong ; hldong6@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Bin-Xiao Su ; Su_luccy@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bax ; Bcl-2-associated X protein ; BBB scores ; Basso&ndash ; Beattie&ndash ; Bresnahan scores ; Bcl-2 ; B-cell lymphoma 2 ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; HE ; hematoxylin and eosin staining ; IL-1β ; interleukin-1 beta ; iNOS ; inducible nitric oxide synthase ; IP ; immunoprecipitation ; NE ; neutrophil elastase ; NF-κB ; nuclear factor kappa light-chain enhancer of activated B cells ; NO ; nitric oxide ; SCI ; spinal cord injury group ; Siah1 ; E3 ubiquitin-protein ligase SIAH1 ; SIV ; sivelestat sodium
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：330
- 期：Complete
- 页码：171-180
- 全文大小：2015 K
文摘
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GAPDH/Siah1 cascade is involved in traumatic spinal cord injury.
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The activation of GAPDH/Siah1 cascade can be attenuated by sivelestat sodium.
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Sivelestat sodium promotes functional recovery by reducing apoptosis and inflammation.
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Sivelestat sodium reduces apoptosis and inflammation via blockade of GAPDH/Siah1.