The small-molecule IAP antagonist AT406 inhibits pancreatic cancer cells in vitro and in vivo
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- 作者：Yongsheng Jianga ; 1 ; Qinghua Menga ; 1 ; Bo Chenb ; 1 ; Haiyu Shena ; Bing Yana ; Baoyou Sunc ; sunbaoyou_sdu@yeah.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pancreatic cancer ; IAPs ; AT406 ; Bcl-2 ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：9 September 2016
- 年：2016
- 卷：478
- 期：1
- 页码：293-299
- 全文大小：928 K
文摘
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AT406 is cytotoxic to established/primary human pancreatic cancer cells.
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AT406 provokes caspase-dependent apoptosis in pancreatic cancer cells.
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AT406 causes degradation of key IAPs and promotes cytochrome C release.
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Bcl-2 inhibition or knockdown dramatically sensitizes Panc-1 cells to AT406.
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Oral administration of AT406 inhibits Panc-1 tumor growth in SCID nude mice.