Radiographic and pathological analysis of small lung adenocarcinoma using the new IASLC classification

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• 作者：T. Honda^a ; ^d ; ^{feather@med.shimane-u.ac.jp} ; T. Kondo^a ; S. Murakami^a ; H. Saito^a ; F. Oshita^a ; H. Ito^b ; M. Tsuboi^b ; H. Nakayama^b ; T. Yokose^c ; Y. Kameda^c ; T. Isobe^d ; K. Yamada^a
• 刊名：Clinical Radiology
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：68
• 期：1
• 页码：e21-e26
• 全文大小：405 K

文摘

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Aim

To analyse the correlation between computed tomography (CT) findings of small lung adenocarcinomas and the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocarcinoma.

Materials and methods

A retrospective review of 300 lung adenocarcinoma lesions (size ¡Ü20?mm) after surgical resection in 295 consecutive patients was performed. Tumours were defined as air-containing type if the ratio of the maximum dimension of the tumour on mediastinal windows to the maximum dimension of the tumour on lung windows was ¡Ü50 % , and as solid-density type if the ratio was >50 % . The incidence between CT findings (air bronchogram, vascular involvement, pleural tags, notches, and spiculation) and pathological findings were investigated.

Results

Of the 142 air-containing lesions, 114 were adenocarcinoma in situ (AIS), 28 were minimally invasive adenocarcinoma (MIA), and none of the lesions were invasive adenocarcinoma. Of the 158 solid-density lesions, 30 were AIS, 24 were MIA, and 104 were invasive adenocarcinoma. Notches and pleural tags were commonly observed in cases of invasive adenocarcinoma (p?<?0.05).

Conclusions

In the air-containing type of small lung adenocarcinomas, AIS and MIA were observed but no cases of invasive adenocarcinoma were found. The presence of notches and pleural tags were a significant factor in invasive adenocarcinoma.