Telocyte implications in human pathology: An overview

详细信息    查看全文

• 作者：Lidia Ibba-Manneschi ; Irene Rosa ; Mirko Manetti ; ^{mirkomanetti@yahoo.it" class="auth_mail" title="E-mail the corresponding author} ; ^{mirko.manetti@unifi.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Telocytes ; Stromal cells ; Pathology ; Chronic inflammation ; Organ fibrosis
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：55
• 期：Complete
• 页码：62-69
• 全文大小：1855 K

文摘

Telocytes are a recently described interstitial cell population widely distributed in the stromal compartment of many organs in vertebrates, including humans. Owing to their close spatial relationship with multiple cell types, telocytes are universally considered as ‘connecting cells’ mostly committed to intercellular signaling by converting the interstitium into an integrated system that drives organ development and contributes to the maintenance of local tissue homeostasis. Increasing evidence indicates that telocytes may cooperate with tissue-resident stem cells to foster organ repair and regeneration, and that telocyte damage and dysfunction may occur in several disorders. The goal of this review is to provide an overview of the most recent findings concerning the implication of telocytes in a variety of pathologic conditions in humans, including heart disease, chronic inflammation and multiorgan fibrosis. Based on recent promising experimental data, there is realistic hope that by targeting telocytes alone or in tandem with stem cells, we might be able to promote organ regeneration and/or prevent irreversible end-stage organ damage in different pathologies.