Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation
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- 作者：Shobhit Saxena1 ; Roger E. Rö ; nn1 ; 2 ; Carolina Guibentif1 ; 2 ; Roksana Moraghebi1 ; Niels-Bjarne Woods1 ; niels-bjarne.woods@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：6
- 期：5
- 页码：692-703
- 全文大小：2922 K
文摘
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cAMP induction increases HSC-like cell generation from human pluripotent stem cells
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cAMP signaling through Epac axis modulates hemogenic endothelium
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cAMP upregulates anti-oxidative mechanisms and creates redox-state balance
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cAMP induction enhances CXCR4 expression in hematopoietic progenitors