Effect of pretreatment of preadipocytes with AA on adipogenesis was investigated.
AA stimulated adipogenesis program during differentiation phase without IBMX.
MRE-269, a selective agonist of IP, was the most potent instead of AA.
Exposure of preadipocytes to AA enhanced biosynthesis of pro-adipogenic PGI2.
AA suppressed endogenous synthesis of anti-adipogenic prostanoids in preadipoccytes.