Effects of low dose ibogaine on subjective mood state and psychological performance

详细信息    查看全文

• 作者：Bridget Forsyth^a ; ^{b.forsyth.otago@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Liana Machado^a ; ^{liana@psy.otago.ac.nz" class="auth_mail" title="E-mail the corresponding author} ; Tim Jowett^b ; ^{timothy.jowett@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author} ; Hannah Jakobi^c ; ^e ; ^{hannahjakobi@aol.com" class="auth_mail" title="E-mail the corresponding author} ; Kira Garbe^c ; ^e ; ^{kira.garbe@googlemail.com" class="auth_mail" title="E-mail the corresponding author} ; Helen Winter^d ; ^{winterhr@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Paul Glue^c ; ^{paul.glue@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ibogaine ; Noribogaine ; Psychological test ; Mood rating
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：2 August 2016
• 年：2016
• 卷：189
• 期：Complete
• 页码：10-13
• 全文大小：395 K

文摘

Root bark from Tabernanthe iboga has been used traditionally in West Africa as a psychoactive substance in religious rituals. In smaller doses it is reported anecdotally to have stimulant properties.

Aim of the study

To evaluate the influence of a single 20 mg ibogaine dose on psychological variables reflecting subjective mood state and a range of cognitive functions.

Materials and methods

21 healthy male volunteers received single 20 mg doses of ibogaine after 6 days pretreatment with double-blind paroxetine or placebo. We compared responses to a battery of psychometric tests and subjective mood ratings performed before and 2 h after ibogaine dosing, and assessed relationships between changes in test scores and concentrations of active moiety (the sum of molar noribogaine and ibogaine concentrations). Psychological tests were chosen based on responsiveness to opioid and serotonergic ligands.

Results

Ibogaine had minimal influence on psychological tests and mood ratings. The ability to selectively ignore distracting spatial information showed some evidence of modulation; however because this effect was limited to the less challenging condition calls into question the reliability of this result.

Conclusion

We were unable to identify stimulant effects after single 20 mg doses of ibogaine. Future research is needed to confirm whether active moiety concentrations impact selective attention abilities while leaving other cognitive functions and mood state unaffected.