Ibogaine and the inhibition of acetylcholinesterase

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• 作者：Kenneth Alper^a ; ^kra1@nyu.edu ; Maarten E.A. Reith^b ; Henry Sershen^c ; ^d
• 关键词：Ibogaine ; Iboga alkaloid ; Acetylcholinesterase ; Addiction ; Muscarinic cholinergic ; Toxicology
• 刊名：Journal of Ethnopharmacology
• 出版年：2012
• 出版时间：15 February 2012
• 年：2012
• 卷：139
• 期：3
• 页码：879-882
• 全文大小：297 K

文摘

Ethnopharmacological relevance

Ibogaine is a psychoactive monoterpine indole alkaloid extracted from the root bark of Tabernanthe iboga Baill. that is used globally in medical and nonmedical settings to treat drug and alcohol addiction, and is of interest as an ethnopharmacological prototype for experimental investigation and pharmaceutical development. The question of whether ibogaine inhibits acetylcholinesterase (AChE) is of pharmacological and toxicological significance.

Materials and methods

AChE activity was evaluated utilizing reaction with Ellman's reagent with physostigmine as a control.

Results

Ibogaine inhibited AChE with an IC₅₀ of 520 ¡À 40 ¦ÌM.

Conclusions

Ibogaine's inhibition of AChE is physiologically negligible, and does not appear to account for observations of functional effects in animals and humans that might otherwise suggest the possible involvement of pathways linked to muscarinic acetylcholine transmission.