Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus
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- 作者：Jie Qinga ; qing282420@163.com" class="auth_mail" title="E-mail the corresponding author ; Rui Luoa ; Yaxin Wangb ; Junxiu Nonga ; Ming Wua ; Yan Shaoa ; Ruoyi Tanga ; Xi Yua ; Zheng Yinb ; yinzheng@mail.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yuna Sunc ; sunyn@moon.ibp.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCV ; NITD008 ; Nucleoside analog ; Polymerase
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：126
- 期：Complete
- 页码：43-54
- 全文大小：2986 K
文摘
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NITD008 suppressed the replication of different strains of HCV.
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The resistance to NITD008 was conferred by mutation in NS5B (S282T).
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The resistance pattern of NITD008 was not completely similar to Sofosbuvir.
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NITD008 displayed significant synergistic effects with Sofosbuvir.