AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy
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- 作者：Yuting Guoa ; b ; 1 ; Jin Mengb ; 1 ; Yinglong Tangb ; Ting Wanga ; Bin Weib ; Run Fenga ; Bing Gongc ; Huiwen Wangb ; Guangju Jib ; gj28@ibp.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Zhongbing Lua ; luzhongbing@ucas.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPK ; Denervation ; Muscle atrophy
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：600
- 期：Complete
- 页码：56-60
- 全文大小：1112 K
文摘
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AMPKα is phosphorylated in atrophic skeletal muscles.
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AMPKα2 deficient TA skeletal muscles are resistant to denervation induced atrophy.
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AMPKα2 deletion attenuates protein degradation in muscle atrophy.