Controlled delivery of icariin on small intestine submucosa for bone tissue engineering

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• 作者：Mei Li^a ; ^b ; ¹ ; Qiaoqiao Gu^a ; ¹ ; Mengjie Chen^a ; ¹ ; Chi Zhang^a ; Songdi Chen^a ; Jiyuan Zhao^a ; ^{zhaojiyuan@nbu.edu.cn}
• 关键词：Small intestinal submucosa (SIS) ; Icariin ; Drug delivery ; Osteoinductivity ; Bone tissue engineering
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：260-267
• 全文大小：1968 K
• 卷排序：71

文摘

SIS, a natural collagenous extracellular matrix, was applied for icariin delivery. Ic-SIS scaffolds achieved slow sustained icariin release for > 30 days. Ic-SIS scaffolds enhanced bone regeneration in a mouse calvarial defect model.