Prognostic impact of intestinal wall thickening in hospitalized patients with heart failure

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• 作者：Yuki Ikeda^a ; Shunsuke Ishii^a ; ^{sishii@med.kitasato-u.ac.jp} ; Teppei Fujita^a ; Yuichiro Iida^a ; Toyoji Kaida^a ; Takeru Nabeta^a ; Emi Maekawa^a ; Tomoyoshi Yanagisawa^a ; Toshimi Koitabashi^a ; Ichiro Takeuchi^a ; Takayuki Inomata^b ; Junya Ako^a
• 关键词：Intestine ; Diastolic dysfunction ; Heart failure ; Prognosis
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：230
• 期：Complete
• 页码：120-126
• 全文大小：509 K
• 卷排序：230

文摘

Intestine-cardiovascular relationship has been increasingly recognized as a key factor in patients with heart disease. We aimed to identify the relationships among intestinal wall edema, cardiac function, and adverse clinical events in hospitalized heart failure (HF) patients.Methods and resultsAbdominal computed tomographic images of 168 hospitalized HF patients were retrospectively investigated for identification of average colon wall thickness (CWT) from the ascending to sigmoid colon. Relationships between average CWT and echocardiographic parameters, blood sampling data, and primary outcomes including readmission for deteriorated HF and all-cause mortality were evaluated. Among the echocardiographic parameters, lower left ventricular diastolic function was correlated with higher average CWT. In multivariate analysis, higher logarithmic C-reactive protein level, lower estimated glomerular filtration rate, lower peripheral blood lymphocyte count, higher E/E′ ratio, and extremely higher/lower defecation frequency were independently correlated with higher average CWT. Multivariate Cox-hazard analysis demonstrated that higher average CWT was independently related to higher incidence of primary outcomes.ConclusionIn hospitalized HF patients, increased CWT was associated with lower cardiac performance, and predicted poorer long-term clinical outcomes.